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polX [2017-03-06 08:59:21]
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polX [2017-03-06 08:59:21]

DNA polymerase X, involved in DNA repair, generates adaptive mutations by error-prone processing of A/P sites
locus
BSU28590
pI
5.31
mw
63.00 kDa
protein length
570 aa Sequence Blast
gene length
1710 bp Sequence Blast
function
DNA repair
product
DNA polymerase X
essential
no
ec
2.7.7.7
synonyms
yshC
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,923,314 -> 2,925,026

    The protein

    Catalyzed reaction/ biological activity

  • template-dependent DNA polymerase, fills single nucleotide gaps [Pubmed|18938175]
  • has intrinsic 3'-5' exonuclease activity for resecting unannealed 3'-termini in gapped DNA substrates [Pubmed|18776221]
  • has intrinsic apurinic/apyrimidinic (AP) endonuclease activity [Pubmed|20974932]

    • Protein family

  • DNA polymerase X family

    • Biological materials

    Mutant

  • MGNA-B003 (yshC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1002 NBRP B. subtilis, Japan]

    • Labs working on this gene/protein

  • [SW|Margarita Salas], Madrid, Spain [http://www.cbm.uam.es/mkfactory.esdomain/webs/CBMSO/plt_LineasInvestigacion.aspx?IdObjeto=28 link]

    • References

    Reviews

  • 22933559

    • Original publications

  • 20974932,18938175,18776221,22844091,24914186,28254425
    • Expression and Regulation
    [[this]]